Manic episode


bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 F30
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 F30
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F30-F39
Name in latin Mania

Summary Statistics

Key figures

All Female Male
Number of individuals 904 491 413
Unadjusted prevalence (%) 0.25 0.25 0.26
Mean age at first event (years) 43.86 42.74 45.19


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.53 [1.06, 6.03] 3.6e-2 71
15 years 0.01 1.71 [0.85, 3.45] 1.3e-1 29
5 years 0.00 3.31 [1.77, 6.19] 1.8e-4 18
1 year 0.00 10.63 [4.97, 22.73] 1.1e-9 12

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: F5_MANIA – Manic episode
GWS hits:

Survival analyses between endpoints


before Manic episode
after Manic episode

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