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Fibrosis and sclerosis of liver

DOID EFO MESH SNOMED PheWeb

FIBROSCLEROLIV

cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K74.2
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K74.2
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

25

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

25

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Check minimum number of events None

25

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Include endpoints None

25

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FIBROSCLEROLIV

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K74
Name in latin Fibrosis et sclerosis hepatis

Summary Statistics

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Key figures

All Female Male
Number of individuals 25 19 6
Unadjusted prevalence (%) 0.01 0.01 0.00
Mean age at first event (years) 51.56 51.13 52.92

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: FIBROSCLEROLIV – Fibrosis and sclerosis of liver
GWS hits:

Survival analyses between endpoints

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Plot

before Fibrosis and sclerosis of liver
after Fibrosis and sclerosis of liver

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Fibrosis and sclerosis of liver

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