Alzheimer disease


Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 G30
Hospital discharge: ICD-9 3310
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 G30
Cause of death: ICD-9 3310
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G30-G32
Name in latin Morbus Alzheimer

Summary Statistics

Key figures

All Female Male
Number of individuals 8030 3409 4621
Unadjusted prevalence (%) 2.26 1.72 2.94
Mean age at first event (years) 79.38 79.46 79.32


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.14 8.32 [7.03, 9.86] <1e-100 4290
15 years 0.02 2.16 [1.81, 2.57] 1.6e-17 973
5 years 0.01 6.47 [5.77, 7.27] <1e-100 1901
1 year 0.00 17.80 [15.92, 19.89] <1e-100 1411

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: G6_ALZHEIMER – Alzheimer disease
GWS hits: 6

Survival analyses between endpoints


before Alzheimer disease
after Alzheimer disease

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Drugs most likely to be purchased after Alzheimer disease