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Alzheimer disease

DOID EFO MESH SNOMED PheWeb

G6_ALZHEIMER

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G30
Hospital discharge: ICD-9 3310
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 G30
Cause of death: ICD-9 3310
Cause of death: ICD-8 $!$

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

8030

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G6_ALZHEIMER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G30-G32
Name in latin Morbus Alzheimer

Summary Statistics

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Key figures

All Female Male
Number of individuals 8030 3409 4621
Unadjusted prevalence (%) 2.26 1.72 2.94
Mean age at first event (years) 79.38 79.46 79.32

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.14 8.32 [7.03, 9.86] <1e-100 4290
15 years 0.02 2.16 [1.81, 2.57] 1.6e-17 973
5 years 0.01 6.47 [5.77, 7.27] <1e-100 1901
1 year 0.00 17.80 [15.92, 19.89] <1e-100 1411

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_ALZHEIMER – Alzheimer disease
GWS hits: 6

Survival analyses between endpoints

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Plot

before Alzheimer disease
after Alzheimer disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Alzheimer disease

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