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Alzheimer’s disease, wide definition

DOID EFO MESH SNOMED PheWeb

G6_AD_WIDE

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F00*, G30
Hospital discharge: ICD-9 3310
Hospital discharge: ICD-8 29010
Cause of death: ICD-10 F00*, G30
Cause of death: ICD-9 3310
Cause of death: ICD-8 29010
KELA reimbursements: KELA codes 307
KELA reimbursements: ICD-10 F00*, G30
Medicine purchases: ATC N06D

11860

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

11210

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Check minimum number of events

Min. number of events 3

11210

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Include endpoints

11210

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G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 11210 4750 6460
Unadjusted prevalence (%) 3.15 2.39 4.10
Mean age at first event (years) 78.21 78.42 78.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.12 6.71 [5.79, 7.77] <1e-100 5014
15 years 0.02 2.39 [2.05, 2.79] 2.0e-28 1621
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_AD_WIDE – Alzheimer’s disease, wide definition
GWS hits: 14

Survival analyses between endpoints

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Plot

before Alzheimer’s disease, wide definition
after Alzheimer’s disease, wide definition

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Drugs most likely to be purchased after Alzheimer’s disease, wide definition

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