Epilepsy

G6_EPLEPSY

epilepsy: A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G40
Hospital discharge: ICD-9 345
Hospital discharge: ICD-8 345
Hospital discharge: excluded ICD-9 3452|3453
Hospital discharge: excluded ICD-8 34520
Cause of death: ICD-10 G40
Cause of death: ICD-9 345
Cause of death: ICD-8 345
Cause of death: excluded ICD-9 3452|3453
Cause of death: excluded ICD-8 34520
KELA reimbursements: KELA codes 111

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

10720

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G6_EPLEPSY

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G40-G47

Summary Statistics

Key figures

All Female Male
Number of individuals 10720 5208 5512
Unadjusted prevalence (%) 3.01 2.62 3.50
Mean age at first event (years) 42.44 38.10 46.55

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.16 [3.37, 5.12] 6.9e-41 2140
15 years 0.01 2.02 [1.72, 2.39] 5.2e-17 686
5 years 0.01 5.16 [4.52, 5.89] <1e-100 616
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_EPLEPSY – Epilepsy
GWS hits:

Survival analyses between endpoints

Plot

before Epilepsy
after Epilepsy

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