Generalized epilepsy, mode (most common among epilepsy diagnosis)

GE_MODE

generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G40.0, G40.1
Hospital discharge: ICD-9 %345[0-1]
Hospital discharge: ICD-8 %345[0-1]
Hospital discharge: excluded ICD-8 34511
Cause of death: ICD-10 G40.0, G40.1
Cause of death: ICD-9 %345[0-1]
Cause of death: ICD-8 %345[0-1]
Cause of death: excluded ICD-8 34511

9390

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Check pre-conditions, main-only, mode, ICD version

Check mode of ICD-10 codes: %345[0-1], %G40[0-1]
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2065

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Check minimum number of events None

2065

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Include endpoints None

2065

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GE_MODE

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 2065 1060 1005
Unadjusted prevalence (%) 0.58 0.53 0.64
Mean age at first event (years) 41.43 37.40 45.69

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.58 [3.93, 7.91] 7.1e-22 375
15 years 0.02 2.19 [1.58, 3.04] 2.5e-6 111
5 years 0.01 5.28 [3.70, 7.53] 4.5e-20 106
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: GE_MODE – Generalized epilepsy, mode (most common among epilepsy diagnosis)
GWS hits:

Survival analyses between endpoints

Plot

before Generalized epilepsy, mode (most common among epilepsy diagnosis)
after Generalized epilepsy, mode (most common among epilepsy diagnosis)

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Drugs most likely to be purchased after Generalized epilepsy, mode (most common among epilepsy diagnosis)