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Normal-pressure hydrocephalus

DOID EFO MESH SNOMED PheWeb

G6_HCNP

normal pressure hydrocephalus: A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see gait disorders, neurologic), progressive intellectual decline, and urinary incontinence. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of csf including subarachnoid hemorrhage, chronic meningitis, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G91.2
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 G91.2
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

673

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

673

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Check minimum number of events None

673

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Include endpoints None

673

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G6_HCNP

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G91
Name in latin Hydrocephalia normotensiva

Summary Statistics

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Key figures

All Female Male
Number of individuals 673 289 384
Unadjusted prevalence (%) 0.19 0.15 0.24
Mean age at first event (years) 70.52 69.69 71.15

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.26 [1.04, 4.90] 3.8e-2 160
15 years 0.01 1.16 [0.60, 2.25] 6.6e-1 59
5 years 0.00 3.41 [2.27, 5.13] 3.5e-9 70
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_HCNP – Normal-pressure hydrocephalus
GWS hits: 1

Survival analyses between endpoints

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Plot

before Normal-pressure hydrocephalus
after Normal-pressure hydrocephalus

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Normal-pressure hydrocephalus

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