Systemic atrophies primarly affecting the central nervous system

DOID MESH PheWeb

G6_NEUATR

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

Apply sex-specific rule None

356077

Check conditions None

356077

Filter registries

Hospital Discharge: ICD-10 G10-G13

Cause of death: ICD-10 G10-G13

860

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

860

Check minimum number of events None

860

Include endpoints

G6_HUNTINGTON

G6_HERATAXIA

G6_INFAMUSC

G6_OTHINMUSC

G6_ALS

G6_SPINAMUSCOTH

G6_POSTPOLIO

1007

G6_NEUATR

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

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Similar endpoints

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List of similar endpoints to Systemic atrophies primarly affecting the central nervous system based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

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Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1007	410	597
Unadjusted prevalence (%)	0.28	0.21	0.38
Mean age at first event (years)	57.55	54.35	59.74

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.12	7.66 [5.65, 10.40]	3.6e-39	330
15 years	0.02	2.34 [1.71, 3.22]	1.4e-7	81
5 years	0.01	7.17 [5.10, 10.06]	6.0e-30	100
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_NEUATR – Systemic atrophies primarly affecting the central nervous system
GWS hits: 4

Survival analyses between endpoints

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Plot

before Systemic atrophies primarly affecting the central nervous system
after Systemic atrophies primarly affecting the central nervous system

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Table

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Drugs most likely to be purchased after Systemic atrophies primarly affecting the central nervous system

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≡ Risteys

R8

R7

R6

R5

R4

R3