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Paraplegia, diplegia of upper limbs

DOID EFO MESH SNOMED PheWeb

G6_PARDIPLE

paraplegia: Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord. [database_cross_reference: NCIT:P378]

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G82.0, G82.1, G82.2, G83.0
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 34401
Cause of death: ICD-10 G82.0, G82.1, G82.2, G83.0
Cause of death: ICD-9 $!$
Cause of death: ICD-8 34401

550

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

550

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Check minimum number of events None

550

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Include endpoints None

550

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G6_PARDIPLE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 550 251 299
Unadjusted prevalence (%) 0.15 0.13 0.19
Mean age at first event (years) 52.57 47.33 56.97

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.15 9.29 [5.90, 14.63] 6.6e-22 126
15 years 0.02 2.88 [1.82, 4.55] 5.7e-6 32
5 years 0.01 7.65 [4.95, 11.83] 5.7e-20 35
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_PARDIPLE – Paraplegia, diplegia of upper limbs
GWS hits: 1

Survival analyses between endpoints

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Plot

before Paraplegia, diplegia of upper limbs
after Paraplegia, diplegia of upper limbs

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Drugs most likely to be purchased after Paraplegia, diplegia of upper limbs

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