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Parkinson's disease

DOID EFO MESH SNOMED PheWeb

G6_PARKINSON

Parkinson's disease: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G20
Hospital discharge: ICD-9 3320A
Hospital discharge: ICD-8 34200
Cause of death: ICD-10 G20
Cause of death: ICD-9 3320A
Cause of death: ICD-8 34200
KELA reimbursements: KELA codes 110

3860

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3860

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Check minimum number of events None

3860

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Include endpoints None

3860

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G6_PARKINSON

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Morbus Parkinson

Summary Statistics

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Key figures

All Female Male
Number of individuals 3860 1544 2316
Unadjusted prevalence (%) 1.08 0.78 1.47
Mean age at first event (years) 65.16 63.55 66.23

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.87 [3.00, 4.99] 2.3e-25 1099
15 years 0.02 2.27 [1.87, 2.75] 5.2e-17 534
5 years 0.00 3.71 [3.16, 4.34] 1.9e-58 387
1 year 0.00 3.73 [2.89, 4.80] 2.1e-24 82

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_PARKINSON – Parkinson's disease
GWS hits: 2

Survival analyses between endpoints

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Plot

before Parkinson's disease
after Parkinson's disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Parkinson's disease

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