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Parkinson's disease, strict definition

DOID EFO MESH SNOMED PheWeb

PDSTRICT

secondary Parkinson disease: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G20
Hospital discharge: ICD-9 3320A
Hospital discharge: ICD-8 34200
Cause of death: ICD-10 G20
Cause of death: ICD-9 3320A
Cause of death: ICD-8 34200
KELA reimbursements: KELA codes 110
KELA reimbursements: ICD-10 G20, G20+F02.39

3860

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3450

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Check minimum number of events None

3450

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Include endpoints None

3450

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PDSTRICT

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Morbus Parkinson

Summary Statistics

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Key figures

All Female Male
Number of individuals 3450 1357 2093
Unadjusted prevalence (%) 0.97 0.68 1.33
Mean age at first event (years) 68.59 67.54 69.27

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.38 [3.52, 5.45] 6.1e-40 1004
15 years 0.02 2.40 [1.92, 3.00] 1.1e-14 498
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: PDSTRICT – Parkinson's disease, strict definition
GWS hits:

Survival analyses between endpoints

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Plot

before Parkinson's disease, strict definition
after Parkinson's disease, strict definition

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Drugs most likely to be purchased after Parkinson's disease, strict definition

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