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Other and unspecified polyneuropathies, also in other diseases

DOID EFO MESH SNOMED PheWeb

G6_POLYOTHUNS

chronic inflammatory demyelinating polyradiculoneuropathy: A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G61.1#, G61.8, G61.9, G62.8, G62.9, G63*, G63.0*B02.29
Hospital discharge: ICD-9 357[8-9]
Hospital discharge: ICD-8 3540[8-9]
Cause of death: ICD-10 G61.1#, G61.8, G61.9, G62.8, G62.9, G63*, G63.0*B02.29
Cause of death: ICD-9 357[8-9]
Cause of death: ICD-8 3540[8-9]

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

5046

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G6_POLYOTHUNS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 5046 1926 3120
Unadjusted prevalence (%) 1.42 0.97 1.98
Mean age at first event (years) 61.92 59.65 63.33

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.37 [2.64, 4.30] 1.3e-22 896
15 years 0.01 1.79 [1.42, 2.24] 5.4e-7 402
5 years 0.00 2.97 [2.36, 3.75] 2.6e-20 280
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_POLYOTHUNS – Other and unspecified polyneuropathies, also in other diseases
GWS hits: 2

Survival analyses between endpoints

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Plot

before Other and unspecified polyneuropathies, also in other diseases
after Other and unspecified polyneuropathies, also in other diseases

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Drugs most likely to be purchased after Other and unspecified polyneuropathies, also in other diseases

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