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Diabetic polyneuropathy

DOID EFO MESH SNOMED PheWeb

DM_POLYNEURO

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G63.2*E10.4, G63.2*E11.4
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 G63.2*E10.4, G63.2*E11.4
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

985

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

956

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Check minimum number of events None

956

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Include endpoints None

956

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DM_POLYNEURO

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 956 336 620
Unadjusted prevalence (%) 0.27 0.17 0.39
Mean age at first event (years) 59.48 56.41 61.14

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.56 [0.93, 7.06] 7.0e-2 186
15 years 0.01 1.69 [0.83, 3.43] 1.5e-1 81
5 years 0.00 3.53 [2.02, 6.19] 1.0e-5 63
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_POLYNEURO – Diabetic polyneuropathy
GWS hits: 1

Survival analyses between endpoints

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Plot

before Diabetic polyneuropathy
after Diabetic polyneuropathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic polyneuropathy

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