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Other extrapyramidal and movement disorders+ in other diseases

DOID EFO MESH SNOMED PheWeb

G6_XTRAPYROTH

Stiff-Person syndrome: Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G25, G26*
Hospital discharge: ICD-9 333
Hospital discharge: ICD-8 $!$
Hospital discharge: excluded ICD-9 3330|3336
Cause of death: ICD-10 G25, G26*
Cause of death: ICD-9 333
Cause of death: ICD-8 $!$
Cause of death: excluded ICD-9 3330|3336

4067

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4061

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Check minimum number of events None

4061

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Include endpoints None

4061

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G6_XTRAPYROTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 4061 2164 1897
Unadjusted prevalence (%) 1.14 1.09 1.21
Mean age at first event (years) 59.90 57.56 62.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.28 [1.67, 3.11] 2.4e-7 501
15 years 0.01 1.43 [1.08, 1.88] 1.1e-2 246
5 years 0.00 2.49 [1.96, 3.16] 7.6e-14 156
1 year 0.00 4.18 [3.01, 5.81] 1.6e-17 51

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_XTRAPYROTH – Other extrapyramidal and movement disorders+ in other diseases
GWS hits: 1

Survival analyses between endpoints

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Plot

before Other extrapyramidal and movement disorders+ in other diseases
after Other extrapyramidal and movement disorders+ in other diseases

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Drugs most likely to be purchased after Other extrapyramidal and movement disorders+ in other diseases

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