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Generalized epilepsy

DOID EFO MESH SNOMED PheWeb

GE

generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G40.3
Hospital discharge: ICD-9 345[0-3]
Hospital discharge: ICD-8 34519
Hospital discharge: excluded ICD-8 34511
Cause of death: ICD-10 G40.3
Cause of death: ICD-9 345[0-3]
Cause of death: ICD-8 34519
Cause of death: excluded ICD-8 34511

1730

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1208

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Check minimum number of events None

1208

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Include endpoints None

1208

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GE

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 1208 732 476
Unadjusted prevalence (%) 0.34 0.37 0.30
Mean age at first event (years) 31.19 29.24 34.20

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.09 [2.56, 6.54] 3.9e-9 123
15 years 0.02 2.83 [1.94, 4.15] 8.5e-8 54
5 years 0.01 4.03 [2.60, 6.24] 4.4e-10 24
1 year 0.00 7.79 [4.04, 15.03] 9.3e-10 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: GE – Generalized epilepsy
GWS hits:

Survival analyses between endpoints

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Plot

before Generalized epilepsy
after Generalized epilepsy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Generalized epilepsy

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