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Hereditary corneal dystrophies

DOID MESH PheWeb

H7_KERATOCONUS

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 H18.5
Hospital discharge: ICD-9 3715
Hospital discharge: ICD-8 37102
Cause of death: ICD-10 H18.5
Cause of death: ICD-9 3715
Cause of death: ICD-8 37102

658

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

658

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Check minimum number of events None

658

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Include endpoints None

658

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H7_KERATOCONUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H18
Name in latin Dystrophia corneae hereditaria

Summary Statistics

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Key figures

All Female Male
Number of individuals 658 441 217
Unadjusted prevalence (%) 0.18 0.22 0.14
Mean age at first event (years) 63.02 62.66 63.75

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.25 [0.38, 4.12] 7.1e-1 46
15 years 0.01 0.74 [0.20, 2.73] 6.6e-1 25
5 years 0.00 1.44 [0.42, 4.95] 5.6e-1 17
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_KERATOCONUS – Hereditary corneal dystrophies
GWS hits: 13

Survival analyses between endpoints

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Plot

before Hereditary corneal dystrophies
after Hereditary corneal dystrophies

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hereditary corneal dystrophies

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