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Aortic valve malfunction, age under 60 years

PheWeb

I9_AORTVALV_EARLY

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I35.0, I35.1, I35.2, I35.8
Hospital discharge: ICD-9 4242[A-C]
Cause of death: ICD-10 I35.0, I35.1, I35.2, I35.8
Cause of death: ICD-9 4242[A-C]

12624

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Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE < 60
Look only at ICD versions H.D: 10, 9 ; C.O.D: 10, 9

2431

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Check minimum number of events None

2431

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Include endpoints None

2431

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I9_AORTVALV_EARLY

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF7

Summary Statistics

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Key figures

All Female Male
Number of individuals 2431 866 1565
Unadjusted prevalence (%) 0.68 0.44 0.99
Mean age at first event (years) 48.62 47.81 49.07

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.58 [2.13, 6.03] 1.5e-6 176
15 years 0.02 2.87 [1.80, 4.58] 1.0e-5 88
5 years 0.01 4.67 [2.83, 7.73] 1.9e-9 32
1 year 0.00 9.43 [4.72, 18.85] 2.1e-10 11

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_AORTVALV_EARLY – Aortic valve malfunction, age under 60 years
GWS hits: 2

Survival analyses between endpoints

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Plot

before Aortic valve malfunction, age under 60 years
after Aortic valve malfunction, age under 60 years

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Aortic valve malfunction, age under 60 years

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