Valvular heart disease excluding rheumatic fever

I9_VHD

heart valve disease: A disease involving the cardial valve.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

75274

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I9_VHD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 75274 35960 39314
Unadjusted prevalence (%) 21.16 18.12 24.98
Mean age at first event (years) 61.12 59.21 62.87

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.61 [3.28, 3.97] <1e-100 9772
15 years 0.01 1.83 [1.67, 2.00] 1.1e-37 3777
5 years 0.00 3.81 [3.53, 4.12] <1e-100 3565
1 year 0.00 10.48 [9.49, 11.58] <1e-100 2009

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_VHD – Valvular heart disease excluding rheumatic fever
GWS hits: 14

Survival analyses between endpoints

Plot

before Valvular heart disease excluding rheumatic fever
after Valvular heart disease excluding rheumatic fever

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Drugs most likely to be purchased after Valvular heart disease excluding rheumatic fever