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Non-rheumatic valve diseases

DOID EFO MESH SNOMED PheWeb

I9_NONRHEVALV

heart valve disease: A disease involving the cardial valve.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I34, I35, I36, I37
Hospital discharge: ICD-9 424
Hospital discharge: ICD-8 39[4-6]|424
Hospital discharge: excluded ICD-8 4249|3940|3950|3960|3970
Cause of death: ICD-10 I34, I35, I36, I37
Cause of death: ICD-9 424
Cause of death: ICD-8 39[4-6]|424
Cause of death: excluded ICD-8 4249|3940|3950|3960|3970

18960

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

18930

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Check minimum number of events None

18930

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Include endpoints None

18930

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I9_NONRHEVALV

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 18930 8050 10880
Unadjusted prevalence (%) 5.32 4.06 6.91
Mean age at first event (years) 66.02 65.49 66.42

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.10 [2.65, 3.62] 1.4e-45 3809
15 years 0.01 1.53 [1.33, 1.75] 1.8e-9 1463
5 years 0.00 3.22 [2.88, 3.60] 9.0e-94 1258
1 year 0.00 10.17 [8.97, 11.54] <1e-100 815

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_NONRHEVALV – Non-rheumatic valve diseases
GWS hits: 6

Survival analyses between endpoints

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Plot

before Non-rheumatic valve diseases
after Non-rheumatic valve diseases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Non-rheumatic valve diseases

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