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Cardiomyopathy, Hypertrophic obstructive

DOID EFO MESH SNOMED PheWeb

I9_CARDMYOHYP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I42.1
Hospital discharge: ICD-9 4251A
Hospital discharge: ICD-8 42500
Cause of death: ICD-10 I42.1
Cause of death: ICD-9 4251A
Cause of death: ICD-8 42500

502

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

502

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Check minimum number of events None

502

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Include endpoints None

502

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I9_CARDMYOHYP

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5
Parent code in ICD-10 I42
Name in latin Cardiomyopathia hypertrophica obstructiva

Summary Statistics

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Key figures

All Female Male
Number of individuals 502 198 304
Unadjusted prevalence (%) 0.14 0.10 0.19
Mean age at first event (years) 55.30 53.80 56.27

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.09 [3.30, 7.85] 1.7e-13 98
15 years 0.01 2.06 [1.27, 3.34] 3.5e-3 35
5 years 0.01 5.28 [3.33, 8.37] 1.4e-12 30
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CARDMYOHYP – Cardiomyopathy, Hypertrophic obstructive
GWS hits: 15

Survival analyses between endpoints

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Plot

before Cardiomyopathy, Hypertrophic obstructive
after Cardiomyopathy, Hypertrophic obstructive

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cardiomyopathy, Hypertrophic obstructive

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