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Major coronary heart disease event

DOID EFO MESH PheWeb

I9_CHD

intermediate coronary syndrome: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I20.0, I21, I22
Hospital discharge: ICD-9 410|4110
Hospital discharge: ICD-8 410|4110
Cause of death: ICD-10 I21, I22, I23, I24, I25, I46, R96, R98
Cause of death: ICD-9 41[0-4]|798
Cause of death: ICD-8 41[0-4]|798
Cause of death: excluded ICD-9 7980A

35449

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Check pre-conditions, main-only, mode, ICD version

Check only main diagnosis Yes, side diagnoses are not checked
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

31599

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Check minimum number of events None

31599

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Include endpoints

40297

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I9_CHD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 40297 11394 28903
Unadjusted prevalence (%) 11.33 5.74 18.37
Mean age at first event (years) 65.85 67.84 65.07

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.10 [3.73, 4.51] <1e-100 14098
15 years 0.01 2.14 [1.96, 2.34] 3.7e-63 4822
5 years 0.00 3.35 [3.10, 3.62] <1e-100 2574
1 year 0.01 34.63 [31.25, 38.38] <1e-100 5197

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CHD – Major coronary heart disease event
GWS hits: 73

Survival analyses between endpoints

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Plot

before Major coronary heart disease event
after Major coronary heart disease event

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Major coronary heart disease event

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