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Myocardial infarction, strict

DOID EFO MESH SNOMED PheWeb

I9_MI_STRICT

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I21, I22
Hospital discharge: ICD-9 410
Hospital discharge: ICD-8 410
Hospital discharge: excluded ICD-10 I21.90, I21.97, I22.90, I22.97
Cause of death: ICD-10 I21, I22
Cause of death: ICD-9 410
Cause of death: ICD-8 410
Cause of death: excluded ICD-10 I21.90, I21.97, I22.90, I22.97

24101

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Check pre-conditions, main-only, mode, ICD version

Check only main diagnosis Yes, side diagnoses are not checked
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

22348

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Check minimum number of events None

22348

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Include endpoints None

22348

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I9_MI_STRICT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4

Summary Statistics

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Key figures

All Female Male
Number of individuals 22348 5651 16697
Unadjusted prevalence (%) 6.28 2.85 10.61
Mean age at first event (years) 66.11 69.27 65.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.34 [2.92, 3.81] 8.6e-70 8613
15 years 0.01 1.68 [1.48, 1.90] 2.1e-16 2884
5 years 0.00 3.04 [2.76, 3.34] <1e-100 1728
1 year 0.01 27.20 [24.43, 30.27] <1e-100 3125

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_MI_STRICT – Myocardial infarction, strict
GWS hits: 46

Survival analyses between endpoints

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Plot

before Myocardial infarction, strict
after Myocardial infarction, strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Myocardial infarction, strict

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