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Heart failure, not strict

DOID EFO MESH SNOMED PheWeb

I9_HEARTFAIL_NS

systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I11.0, I13.0, I13.2, I50
Hospital discharge: ICD-9 4029B|428
Hospital discharge: ICD-8 42700|42710|428|7824
Cause of death: ICD-10 I11.0, I13.0, I13.2, I50
Cause of death: ICD-9 4029B|428
Cause of death: ICD-8 42700|42710|428|7824
KELA reimbursements: KELA codes 201
Medicine purchases: ATC C03CA01|C03EB01

59112

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

44053

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Check minimum number of events

Min. number of events 3

44053

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Include endpoints None

44053

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I9_HEARTFAIL_NS

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF6

Summary Statistics

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Key figures

All Female Male
Number of individuals 44053 18620 25433
Unadjusted prevalence (%) 12.38 9.38 16.16
Mean age at first event (years) 66.36 64.65 67.61

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 5.63 [5.16, 6.15] <1e-100 15760
15 years 0.02 3.11 [2.87, 3.37] <1e-100 6365
5 years 0.01 5.27 [4.92, 5.66] <1e-100 5464
1 year 0.00 11.81 [10.64, 13.10] <1e-100 2729

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HEARTFAIL_NS – Heart failure, not strict
GWS hits: 11

Survival analyses between endpoints

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Plot

before Heart failure, not strict
after Heart failure, not strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Heart failure, not strict

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