Heart failure, not strict

I9_HEARTFAIL_NS

systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I11.0, I13.0, I13.2, I50
Hospital discharge: ICD-9 4029B|428
Hospital discharge: ICD-8 42700|42710|428|7824
Cause of death: ICD-10 I11.0, I13.0, I13.2, I50
Cause of death: ICD-9 4029B|428
Cause of death: ICD-8 42700|42710|428|7824
KELA reimbursements: KELA codes 201
Medicine purchases: ATC C03CA01|C03EB01

59112

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

44053

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Check minimum number of events

Min. number of events 3

44053

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Include endpoints None

44053

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I9_HEARTFAIL_NS

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF6

Summary Statistics

Key figures

All Female Male
Number of individuals 44053 18620 25433
Unadjusted prevalence (%) 12.38 9.38 16.16
Mean age at first event (years) 66.36 64.65 67.61

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 5.63 [5.16, 6.15] <1e-100 15760
15 years 0.02 3.11 [2.87, 3.37] <1e-100 6365
5 years 0.01 5.27 [4.92, 5.66] <1e-100 5464
1 year 0.00 11.81 [10.64, 13.10] <1e-100 2729

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_HEARTFAIL_NS – Heart failure, not strict
GWS hits: 11

Survival analyses between endpoints

Plot

before Heart failure, not strict
after Heart failure, not strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Heart failure, not strict