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All-cause Heart Failure

DOID EFO MESH SNOMED PheWeb

I9_HEARTFAIL_ALLCAUSE

congestive heart failure: Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not I9_HYPERTROCARDMYOP

355107

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

24420

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I9_HEARTFAIL_ALLCAUSE

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 24420 8813 15607
Unadjusted prevalence (%) 6.86 4.44 9.92
Mean age at first event (years) 69.05 69.01 69.08

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.65 [4.17, 5.19] <1e-100 10656
15 years 0.02 2.51 [2.29, 2.75] 7.8e-86 4295
5 years 0.01 4.09 [3.79, 4.43] <1e-100 3348
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HEARTFAIL_ALLCAUSE – All-cause Heart Failure
GWS hits: 7

Survival analyses between endpoints

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Plot

before All-cause Heart Failure
after All-cause Heart Failure

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after All-cause Heart Failure

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