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Heart failure,strict

DOID EFO MESH SNOMED PheWeb

I9_HEARTFAIL

systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I11.0, I13.0, I13.2, I50
Hospital discharge: ICD-9 4029B|428
Hospital discharge: ICD-8 42700|42710|428|7824
Cause of death: ICD-10 I11.0, I13.0, I13.2, I50
Cause of death: ICD-9 4029B|428
Cause of death: ICD-8 42700|42710|428|7824
KELA reimbursements: KELA codes 201
Medicine purchases: ATC C03CA01|C03EB01

24874

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

24818

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Check minimum number of events

Min. number of events 3, and need other rules

24818

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Include endpoints None

24818

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I9_HEARTFAIL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF6

Summary Statistics

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Key figures

All Female Male
Number of individuals 24818 8947 15871
Unadjusted prevalence (%) 6.98 4.51 10.08
Mean age at first event (years) 68.90 68.89 68.91

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.63 [4.12, 5.19] <1e-100 10785
15 years 0.02 2.50 [2.27, 2.76] 5.9e-78 4363
5 years 0.01 4.09 [3.78, 4.42] <1e-100 3379
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HEARTFAIL – Heart failure,strict
GWS hits:

Survival analyses between endpoints

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Plot

before Heart failure,strict
after Heart failure,strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Heart failure,strict

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