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Hypertrophic cardiomyopathy

DOID EFO MESH SNOMED PheWeb

I9_HYPERTROCARDMYOP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I42.1, I42.2
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 I42.1, I42.2
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

970

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

970

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Check minimum number of events None

970

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Include endpoints None

970

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I9_HYPERTROCARDMYOP

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 970 381 589
Unadjusted prevalence (%) 0.27 0.19 0.37
Mean age at first event (years) 57.80 55.45 59.33

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 6.81 [4.16, 11.16] 2.7e-14 191
15 years 0.02 2.97 [1.92, 4.58] 8.8e-7 64
5 years 0.01 6.82 [4.58, 10.14] 2.8e-21 57
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HYPERTROCARDMYOP – Hypertrophic cardiomyopathy
GWS hits: 25

Survival analyses between endpoints

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Plot

before Hypertrophic cardiomyopathy
after Hypertrophic cardiomyopathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertrophic cardiomyopathy

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