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Barret oesophagus

DOID EFO MESH SNOMED PheWeb

K11_BARRET

Barrett's esophagus: Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas. (WHO)

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K22.7
Hospital discharge: ICD-9 5301B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K22.7
Cause of death: ICD-9 5301B
Cause of death: ICD-8 $!$

964

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

964

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Check minimum number of events None

964

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Include endpoints None

964

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K11_BARRET

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K22

Summary Statistics

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Key figures

All Female Male
Number of individuals 964 334 630
Unadjusted prevalence (%) 0.27 0.17 0.40
Mean age at first event (years) 64.79 64.82 64.78

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.13 8.72 [5.48, 13.86] 5.3e-20 70
15 years 0.02 2.49 [1.39, 4.45] 2.2e-3 19
5 years 0.01 6.26 [3.68, 10.64] 1.3e-11 32
1 year 0.00 12.93 [6.55, 25.54] 1.7e-13 16

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_BARRET – Barret oesophagus
GWS hits:

Survival analyses between endpoints

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Plot

before Barret oesophagus
after Barret oesophagus

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Barret oesophagus

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