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Diseases of oesophagus, stomach and duodenum

DOID EFO MESH SNOMED PheWeb

K11_OESSTODUO

gastric mucosal hypertrophy: MC)nC)trier disease (MD) is a rare premalignant hyperproliferative gastropathy characterized by massive overgrowth of foveolar cells in the gastric lining, resulting in large gastric folds, and manifesting with epigastric pain, nausea, vomiting, peripheral edema and, less commonly, anorexia and weight loss.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K20, K20#, K20-K31
Cause of death: ICD-10 K20, K20#, K20-K31

48844

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

48844

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Check minimum number of events None

48844

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Include endpoints

52113

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K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 52113 28052 24061
Unadjusted prevalence (%) 14.65 14.14 15.29
Mean age at first event (years) 55.27 53.42 57.42

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.11 [1.90, 2.34] 7.2e-45 7663
15 years 0.01 1.33 [1.21, 1.45] 1.0e-9 3176
5 years 0.00 2.67 [2.46, 2.90] <1e-100 2046
1 year 0.00 8.02 [7.20, 8.94] <1e-100 1198

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_OESSTODUO – Diseases of oesophagus, stomach and duodenum
GWS hits: 1

Survival analyses between endpoints

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Plot

before Diseases of oesophagus, stomach and duodenum
after Diseases of oesophagus, stomach and duodenum

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diseases of oesophagus, stomach and duodenum

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