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Cholangitis (primary sclerosing, PSC)

DOID EFO MESH SNOMED PheWeb

K11_CHOLANGI

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K83.0
Hospital discharge: ICD-9 5761
Hospital discharge: ICD-8 5750[4-5]
Cause of death: ICD-10 K83.0
Cause of death: ICD-9 5761
Cause of death: ICD-8 5750[4-5]

1537

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1537

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Check minimum number of events None

1537

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Include endpoints None

1537

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K11_CHOLANGI

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K83
Name in latin Cholangitis

Similar endpoints

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List of similar endpoints to Cholangitis (primary sclerosing, PSC) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 1537 732 805
Unadjusted prevalence (%) 0.43 0.37 0.51
Mean age at first event (years) 58.12 55.76 60.27

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.36 [2.55, 7.45] 6.8e-8 341
15 years 0.01 1.33 [0.86, 2.07] 2.0e-1 79
5 years 0.01 4.46 [3.21, 6.19] 5.1e-19 96
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_CHOLANGI – Cholangitis (primary sclerosing, PSC)
GWS hits: 1

Survival analyses between endpoints

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Plot

before Cholangitis (primary sclerosing, PSC)
after Cholangitis (primary sclerosing, PSC)

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Drugs most likely to be purchased after Cholangitis (primary sclerosing, PSC)

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