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Functional dyspepsia

DOID EFO MESH PheWeb

K11_FUNCDYSP

dyspepsia: An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K30
Hospital discharge: ICD-9 5368A
Hospital discharge: ICD-8 5361
Cause of death: ICD-10 K30
Cause of death: ICD-9 5368A
Cause of death: ICD-8 5361

8026

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

8021

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Check minimum number of events None

8021

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Include endpoints None

8021

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K11_FUNCDYSP

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K20-K31
Name in latin Dyspepsia

Summary Statistics

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Key figures

All Female Male
Number of individuals 8021 5486 2535
Unadjusted prevalence (%) 2.25 2.77 1.61
Mean age at first event (years) 53.63 51.95 57.25

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.11 [1.66, 2.69] 1.8e-9 582
15 years 0.01 1.29 [1.03, 1.62] 2.8e-2 258
5 years 0.00 2.35 [1.86, 2.97] 1.0e-12 170
1 year 0.00 5.31 [3.98, 7.09] 9.8e-30 74

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_FUNCDYSP – Functional dyspepsia
GWS hits:

Survival analyses between endpoints

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Plot

before Functional dyspepsia
after Functional dyspepsia

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Drugs most likely to be purchased after Functional dyspepsia

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