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Gastro-oesophageal reflux disease

DOID EFO MESH SNOMED PheWeb

K11_REFLUX

gastroesophageal reflux disease: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K21
Hospital discharge: ICD-9 5301A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K21
Cause of death: ICD-9 5301A
Cause of death: ICD-8 $!$

23702

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

23702

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Check minimum number of events None

23702

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Include endpoints None

23702

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K11_REFLUX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K20-K31
Name in latin Morbus refluxualis gastro-oesophageus

Summary Statistics

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Key figures

All Female Male
Number of individuals 23702 13707 9995
Unadjusted prevalence (%) 6.66 6.91 6.35
Mean age at first event (years) 54.69 53.62 56.16

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.87 [1.57, 2.24] 6.5e-12 2024
15 years 0.01 1.25 [1.08, 1.45] 3.2e-3 940
5 years 0.00 2.29 [2.00, 2.62] 2.7e-33 532
1 year 0.00 4.99 [4.18, 5.96] 5.5e-71 219

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_REFLUX – Gastro-oesophageal reflux disease
GWS hits:

Survival analyses between endpoints

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Plot

before Gastro-oesophageal reflux disease
after Gastro-oesophageal reflux disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Gastro-oesophageal reflux disease

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