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Coxarthrosis,

DOID EFO MESH PheWeb

M13_ARTHTROSIS_COX

osteoarthritis: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M16
Hospital discharge: ICD-9 7151E|7152E
Hospital discharge: ICD-8 71300
Cause of death: ICD-10 M16
Cause of death: ICD-9 7151E|7152E
Cause of death: ICD-8 71300

20007

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

20007

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Check minimum number of events None

20007

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Include endpoints None

20007

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M13_ARTHTROSIS_COX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M15-M19
Name in latin Coxarthrosis

Summary Statistics

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Key figures

All Female Male
Number of individuals 20007 10656 9351
Unadjusted prevalence (%) 5.62 5.37 5.94
Mean age at first event (years) 64.05 63.77 64.37

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.55 [1.36, 1.77] 1.0e-10 2631
15 years 0.01 1.06 [0.94, 1.19] 3.6e-1 1339
5 years 0.00 1.55 [1.38, 1.73] 7.7e-14 644
1 year 0.00 1.84 [1.52, 2.23] 5.1e-10 146

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_ARTHTROSIS_COX – Coxarthrosis,
GWS hits: 40

Survival analyses between endpoints

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Plot

before Coxarthrosis,
after Coxarthrosis,

loading spinner Loading survival analyses plot