Finngen Rheumatological endpoints

RHEUMA_ENDPOINTS

rheumatic disease: Inflammatory and degenerative diseases of connective tissue structures, such as arthritis.

Endpoint definition

FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector

Filter registries None

0

diagram downward connector

Check pre-conditions, main-only, mode, ICD version None

0

diagram downward connector

Check minimum number of events None

0

diagram downward connector
RHEUMA_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 83787 48106 35681
Unadjusted prevalence (%) 23.55 24.25 22.67
Mean age at first event (years) 56.07 54.66 57.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.45 [1.33, 1.58] 1.0e-16 9664
15 years 0.01 1.05 [0.97, 1.13] 2.6e-1 4531
5 years 0.00 1.74 [1.62, 1.87] 6.8e-51 2247
1 year 0.00 3.19 [2.86, 3.57] 1.1e-92 783

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: RHEUMA_ENDPOINTS – Finngen Rheumatological endpoints
GWS hits:

Survival analyses between endpoints

Plot

before Finngen Rheumatological endpoints
after Finngen Rheumatological endpoints

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Finngen Rheumatological endpoints