Other specified/unspecified systemic involvement of connective tissue

M13_CONNECTNAS

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M35.8, M35.9
Hospital discharge: ICD-9 710[8-9]
Hospital discharge: ICD-8 7349[1-9]
Cause of death: ICD-10 M35.8, M35.9
Cause of death: ICD-9 710[8-9]
Cause of death: ICD-8 7349[1-9]

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

1554

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M13_CONNECTNAS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1554 1217 337
Unadjusted prevalence (%) 0.44 0.61 0.21
Mean age at first event (years) 49.64 48.08 55.29

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.89 [1.11, 3.21] 1.9e-2 141
15 years 0.01 1.41 [0.88, 2.26] 1.6e-1 61
5 years 0.00 2.38 [1.52, 3.74] 1.6e-4 34
1 year 0.00 6.64 [4.02, 10.98] 1.6e-13 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_CONNECTNAS – Other specified/unspecified systemic involvement of connective tissue
GWS hits: 2

Survival analyses between endpoints

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Plot

before Other specified/unspecified systemic involvement of connective tissue
after Other specified/unspecified systemic involvement of connective tissue

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Drugs most likely to be purchased after Other specified/unspecified systemic involvement of connective tissue

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