Other specified/unspecified systemic involvement of connective tissue

M13_CONNECTNAS

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 M35.8, M35.9
Hospital discharge: ICD-9 710[8-9]
Hospital discharge: ICD-8 7349[1-9]
Cause of death: ICD-10 M35.8, M35.9
Cause of death: ICD-9 710[8-9]
Cause of death: ICD-8 7349[1-9]

-

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

-

diagram downward connector

Check minimum number of events None

-

diagram downward connector

Include endpoints None

1554

diagram downward connector
M13_CONNECTNAS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1554 1217 337
Unadjusted prevalence (%) 0.44 0.61 0.21
Mean age at first event (years) 49.64 48.08 55.29

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.89 [1.11, 3.21] 1.9e-2 141
15 years 0.01 1.41 [0.88, 2.26] 1.6e-1 61
5 years 0.00 2.38 [1.52, 3.74] 1.6e-4 34
1 year 0.00 6.64 [4.02, 10.98] 1.6e-13 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_CONNECTNAS – Other specified/unspecified systemic involvement of connective tissue
GWS hits: 2

Survival analyses between endpoints

Plot

before Other specified/unspecified systemic involvement of connective tissue
after Other specified/unspecified systemic involvement of connective tissue

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other specified/unspecified systemic involvement of connective tissue