causalgia: Complex regional pain syndrome type 2 (CRPS2), or causalgia is a form of complex regional pain syndrome that develops after damage to a peripheral nerve and is characterized by spontaneous pain, allodynia and hyperalgesia , not necessarily limited to the territory of the injured nerve, as well as at some point, edema, changes in skin blood flow or sudomotor dysfunction in the pain area.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries None


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Check pre-conditions, main-only, mode, ICD version None


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Check minimum number of events None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 53576 32808 20768
Unadjusted prevalence (%) 15.06 16.54 13.20
Mean age at first event (years) 50.49 49.25 52.45


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.65 [1.46, 1.87] 3.5e-15 4687
15 years 0.01 1.03 [0.92, 1.15] 6.2e-1 1822
5 years 0.00 2.28 [2.05, 2.54] 1.7e-52 1252
1 year 0.00 6.21 [5.46, 7.07] <1e-100 667

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_DORSALGIA – Dorsalgia
GWS hits: 15

Survival analyses between endpoints


before Dorsalgia
after Dorsalgia

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