Diseases of the musculoskeletal system and connective tissue

XIII_MUSCULOSKELET

No definition available.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M00-M99, M90.6*C40.99, M90.6*C41.99
Hospital discharge: ICD-9 7[1-3]
Hospital discharge: ICD-8 7[1-3]
Cause of death: ICD-10 M00-M99, M90.6*C40.99, M90.6*C41.99
Cause of death: ICD-9 7[1-3]
Cause of death: ICD-8 7[1-3]

200423

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

200423

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Check minimum number of events None

200423

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Include endpoints None

200423

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XIII_MUSCULOSKELET

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 200423 114705 85718
Unadjusted prevalence (%) 56.33 57.81 54.47
Mean age at first event (years) 46.79 45.20 48.91

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.35 [1.26, 1.45] 4.0e-18 19591
15 years 0.01 0.97 [0.91, 1.03] 3.2e-1 8766
5 years 0.00 1.53 [1.44, 1.62] 3.5e-42 3714
1 year 0.00 3.19 [2.87, 3.54] <1e-100 1414

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: XIII_MUSCULOSKELET – Diseases of the musculoskeletal system and connective tissue
GWS hits:

Survival analyses between endpoints

Plot

before Diseases of the musculoskeletal system and connective tissue
after Diseases of the musculoskeletal system and connective tissue

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diseases of the musculoskeletal system and connective tissue