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Giant cell arteritis

DOID EFO MESH SNOMED PheWeb

M13_GIANTCELL

temporal arteritis: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M31.5, M31.6
Hospital discharge: ICD-9 4465
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M31.5, M31.6
Cause of death: ICD-9 4465
Cause of death: ICD-8 $!$

913

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

913

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Check minimum number of events None

913

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Include endpoints

913

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M13_GIANTCELL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 913 544 369
Unadjusted prevalence (%) 0.26 0.27 0.23
Mean age at first event (years) 68.28 67.51 69.42

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.76 [3.57, 6.35] 2.3e-26 152
15 years 0.01 2.02 [1.48, 2.76] 9.1e-6 61
5 years 0.00 3.29 [2.26, 4.79] 5.9e-10 53
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_GIANTCELL – Giant cell arteritis
GWS hits:

Survival analyses between endpoints

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Plot

before Giant cell arteritis
after Giant cell arteritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Giant cell arteritis

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