Other intervertebral disc disorders

M13_INTERVERTEB

lumbar disc degeneration: Any disease of a degenerative nature that affects the intervertebral disc.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M51
Hospital discharge: ICD-9 722
Hospital discharge: ICD-8 725
Hospital discharge: excluded ICD-9 7220|7224|7227|7228A
Hospital discharge: excluded ICD-8 7250
Cause of death: ICD-10 M51
Cause of death: ICD-9 722
Cause of death: ICD-8 725
Cause of death: excluded ICD-9 7220|7224|7227|7228A
Cause of death: excluded ICD-8 7250

34982

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

34385

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Check minimum number of events None

34385

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Include endpoints None

34385

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M13_INTERVERTEB

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M50-M54
Name in latin Aliae morbositates discorum intervertebralium

Summary Statistics

Key figures

All Female Male
Number of individuals 34385 19328 15057
Unadjusted prevalence (%) 9.66 9.74 9.57
Mean age at first event (years) 49.80 49.27 50.47

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.13 [0.98, 1.32] 1.0e-1 2584
15 years 0.01 0.90 [0.80, 1.03] 1.3e-1 1246
5 years 0.00 1.31 [1.15, 1.50] 4.7e-5 463
1 year 0.00 1.60 [1.28, 2.01] 4.4e-5 100

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_INTERVERTEB – Other intervertebral disc disorders
GWS hits: 25

Survival analyses between endpoints

Plot

before Other intervertebral disc disorders
after Other intervertebral disc disorders

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Drugs most likely to be purchased after Other intervertebral disc disorders