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Mixed connective tissue disease

PheWeb

M13_MCTD

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M35.9
Hospital discharge: ICD-9 7109
Hospital discharge: ICD-8 73499
Cause of death: ICD-10 M35.9
Cause of death: ICD-9 7109
Cause of death: ICD-8 73499

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints

1694

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M13_MCTD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF7

Summary Statistics

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Key figures

All Female Male
Number of individuals 1694 1344 350
Unadjusted prevalence (%) 0.48 0.68 0.22
Mean age at first event (years) 50.97 49.26 57.51

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.36 [1.21, 4.59] 1.2e-2 142
15 years 0.01 1.43 [0.72, 2.81] 3.1e-1 66
5 years 0.00 3.01 [1.76, 5.14] 5.7e-5 39
1 year 0.00 6.45 [3.62, 11.51] 2.6e-10 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_MCTD – Mixed connective tissue disease
GWS hits: 4

Survival analyses between endpoints

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Plot

before Mixed connective tissue disease
after Mixed connective tissue disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mixed connective tissue disease

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