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Sicca syndrome [Sjögren]

DOID EFO MESH SNOMED PheWeb

M13_SJOGREN

Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M35.0
Hospital discharge: ICD-9 7102
Hospital discharge: ICD-8 73490
Cause of death: ICD-10 M35.0
Cause of death: ICD-9 7102
Cause of death: ICD-8 73490

2306

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2306

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Check minimum number of events None

2306

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Include endpoints None

2306

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M13_SJOGREN

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M35
Name in latin Syndroma Sjögren

Summary Statistics

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Key figures

All Female Male
Number of individuals 2306 1988 318
Unadjusted prevalence (%) 0.65 1.00 0.20
Mean age at first event (years) 53.15 52.52 57.11

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.59 [1.78, 3.77] 7.0e-7 175
15 years 0.01 2.00 [1.43, 2.82] 6.5e-5 86
5 years 0.00 3.18 [2.20, 4.60] 7.0e-10 39
1 year 0.00 8.38 [5.17, 13.58] 6.1e-18 20

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SJOGREN – Sicca syndrome [Sjögren]
GWS hits: 2

Survival analyses between endpoints

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Plot

before Sicca syndrome [Sjögren]
after Sicca syndrome [Sjögren]

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Drugs most likely to be purchased after Sicca syndrome [Sjögren]

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