Sicca syndrome [Sjögren]


Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M35.0
Hospital discharge: ICD-9 7102
Hospital discharge: ICD-8 73490
Cause of death: ICD-10 M35.0
Cause of death: ICD-9 7102
Cause of death: ICD-8 73490


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M35
Name in latin Syndroma Sjögren

Summary Statistics

Key figures

All Female Male
Number of individuals 2306 1988 318
Unadjusted prevalence (%) 0.65 1.00 0.20
Mean age at first event (years) 53.15 52.52 57.11


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.59 [1.78, 3.77] 7.0e-7 175
15 years 0.01 2.00 [1.43, 2.82] 6.5e-5 86
5 years 0.00 3.18 [2.20, 4.60] 7.0e-10 39
1 year 0.00 8.38 [5.17, 13.58] 6.1e-18 20

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_SJOGREN – Sicca syndrome [Sjögren]
GWS hits: 2

Survival analyses between endpoints


before Sicca syndrome [Sjögren]
after Sicca syndrome [Sjögren]

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Drugs most likely to be purchased after Sicca syndrome [Sjögren]