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Nonalcoholic fatty liver disease

DOID EFO MESH SNOMED PheWeb

NAFLD

non-alcoholic fatty liver disease: A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K76.0
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K76.0
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

1981

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1981

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Check minimum number of events None

1981

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Include endpoints None

1981

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NAFLD

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K76
Name in latin Degeneratio adiposa hepatis non alibi classificata

Summary Statistics

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Key figures

All Female Male
Number of individuals 1981 1121 860
Unadjusted prevalence (%) 0.56 0.57 0.55
Mean age at first event (years) 52.91 53.96 51.54

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.03 [3.37, 7.50] 2.7e-15 130
15 years 0.02 2.95 [2.02, 4.31] 2.5e-8 61
5 years 0.01 4.51 [2.90, 7.01] 2.1e-11 36
1 year 0.00 14.47 [8.36, 25.07] 1.5e-21 24

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: NAFLD – Nonalcoholic fatty liver disease
GWS hits: 6

Survival analyses between endpoints

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Plot

before Nonalcoholic fatty liver disease
after Nonalcoholic fatty liver disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Nonalcoholic fatty liver disease

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