≡ Risteys
R8

Documentation Changelog GitHub Contact & Feedback

Nonalcoholic steatohepatitis

DOID EFO MESH SNOMED PheWeb

NASH

Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.

Endpoint definition

↥
FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 K73.80
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K73.80
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

137

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

137

diagram downward connector

Check minimum number of events None

137

diagram downward connector

Include endpoints None

137

diagram downward connector
NASH

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K73

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 137 83 54
Unadjusted prevalence (%) 0.04 0.04 0.03
Mean age at first event (years) 56.86 58.27 54.70

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: NASH – Nonalcoholic steatohepatitis
GWS hits: 1

Survival analyses between endpoints

↥

Plot

before Nonalcoholic steatohepatitis
after Nonalcoholic steatohepatitis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Nonalcoholic steatohepatitis

↥