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Pre-eclampsia or eclampsia

DOID EFO MESH SNOMED PheWeb

O15_PRE_OR_ECLAMPSIA

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule

Sex only females

198506

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Check conditions None

198506

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Filter registries

Hospital Discharge: ICD-10 O11, O14, O15
Hospital discharge: ICD-9 642[4-7]
Hospital discharge: ICD-8 6370[349]|63710|63799|66120
Cause of death: ICD-10 O11, O14, O15
Cause of death: ICD-9 642[4-7]
Cause of death: ICD-8 6370[349]|63710|63799|66120

6624

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6624

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Check minimum number of events None

6624

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Include endpoints None

6624

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O15_PRE_OR_ECLAMPSIA

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 6624 6624 -
Unadjusted prevalence (%) 1.86 3.34 -
Mean age at first event (years) 29.06 29.06 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.69 [0.48, 0.97] 3.6e-2 122
15 years 0.00 0.39 [0.25, 0.62] 5.4e-5 31
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: O15_PRE_OR_ECLAMPSIA – Pre-eclampsia or eclampsia
GWS hits: 1

Survival analyses between endpoints

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Plot

before Pre-eclampsia or eclampsia
after Pre-eclampsia or eclampsia

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Drugs most likely to be purchased after Pre-eclampsia or eclampsia

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