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Dementia due to Parkinsons disease

DOID EFO MESH PheWeb

PD_DEMENTIA

obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F02.3*, F02.39*
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 F02.3*, F02.39*
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

474

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

474

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Check minimum number of events None

474

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Include endpoints None

474

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PD_DEMENTIA

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 474 154 320
Unadjusted prevalence (%) 0.13 0.08 0.20
Mean age at first event (years) 75.57 76.15 75.28

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: PD_DEMENTIA – Dementia due to Parkinsons disease
GWS hits:

Survival analyses between endpoints

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Plot

before Dementia due to Parkinsons disease
after Dementia due to Parkinsons disease

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Drugs most likely to be purchased after Dementia due to Parkinsons disease

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