COPD/asthma/ILD related pneumonia or pneumonia derived septichaemia

PULM_PNEUMONIA_SEPSIS

pneumonia: An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, caused by an infection in one or both of the lungs (by bacteria, viruses, fungi, or mycoplasma.). Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

53585

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PULM_PNEUMONIA_SEPSIS

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to COPD/asthma/ILD related pneumonia or pneumonia derived septichaemia based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 53585 22096 31489
Unadjusted prevalence (%) 15.06 11.14 20.01
Mean age at first event (years) 56.71 51.89 60.09

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 6.83 [6.15, 7.60] <1e-100 15849
15 years 0.01 2.50 [2.24, 2.80] 1.3e-57 3271
5 years 0.01 7.22 [6.69, 7.80] <1e-100 4489
1 year 0.01 41.45 [37.66, 45.61] <1e-100 7370

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: PULM_PNEUMONIA_SEPSIS – COPD/asthma/ILD related pneumonia or pneumonia derived septichaemia
GWS hits:

Survival analyses between endpoints

Plot

before COPD/asthma/ILD related pneumonia or pneumonia derived septichaemia
after COPD/asthma/ILD related pneumonia or pneumonia derived septichaemia

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Drugs most likely to be purchased after COPD/asthma/ILD related pneumonia or pneumonia derived septichaemia