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Seropositive rheumatoid arthritis, wide

DOID EFO MESH SNOMED PheWeb

RHEUMA_SEROPOS_WIDE

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M05
Hospital discharge: ICD-9 7140A|7141
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M05
Cause of death: ICD-9 7140A|7141
Cause of death: ICD-8 $!$

8481

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

8475

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Check minimum number of events None

8475

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Include endpoints None

8475

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RHEUMA_SEROPOS_WIDE

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M05-M14
Name in latin Arthritis rheumatoides seropositiva

Summary Statistics

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Key figures

All Female Male
Number of individuals 8475 5815 2660
Unadjusted prevalence (%) 2.38 2.93 1.69
Mean age at first event (years) 54.42 52.56 58.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.42 [1.94, 3.03] 5.3e-15 1145
15 years 0.01 1.69 [1.40, 2.04] 3.0e-8 558
5 years 0.00 2.35 [1.98, 2.78] 3.9e-23 252
1 year 0.00 3.41 [2.61, 4.46] 3.7e-19 69

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SEROPOS_WIDE – Seropositive rheumatoid arthritis, wide
GWS hits: 22

Survival analyses between endpoints

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Plot

before Seropositive rheumatoid arthritis, wide
after Seropositive rheumatoid arthritis, wide

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Seropositive rheumatoid arthritis, wide

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