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Other/unspecified seropositiverheumatoid arthritis

DOID EFO MESH SNOMED PheWeb

RHEUMA_SEROPOS_OTH

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M05.8, M05.9
Hospital discharge: ICD-9 7140A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M05.8, M05.9
Cause of death: ICD-9 7140A
Cause of death: ICD-8 $!$

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

8380

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RHEUMA_SEROPOS_OTH

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 8380 5760 2620
Unadjusted prevalence (%) 2.36 2.90 1.66
Mean age at first event (years) 54.42 52.54 58.56

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.78 [1.33, 2.38] 1.0e-4 1130
15 years 0.01 1.41 [1.13, 1.76] 2.1e-3 553
5 years 0.00 2.11 [1.75, 2.53] 3.4e-15 249
1 year 0.00 2.96 [2.23, 3.93] 7.0e-14 65

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SEROPOS_OTH – Other/unspecified seropositiverheumatoid arthritis
GWS hits: 23

Survival analyses between endpoints

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Plot

before Other/unspecified seropositiverheumatoid arthritis
after Other/unspecified seropositiverheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other/unspecified seropositiverheumatoid arthritis

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