Systemic sclerosis,strict definition

SYSTSCLE_STRICT

scleroderma: Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc) (see these terms).

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

SYSTSCLE_ICD10

549

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Filter registries

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M34

466

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Check pre-conditions, main-only, mode, ICD version None

183

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Check minimum number of events None

183

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Include endpoints None

183

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SYSTSCLE_STRICT

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 183 160 23
Unadjusted prevalence (%) 0.05 0.08 0.01
Mean age at first event (years) 54.14 53.93 55.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: SYSTSCLE_STRICT – Systemic sclerosis,strict definition
GWS hits: 1

Survival analyses between endpoints

Plot

before Systemic sclerosis,strict definition
after Systemic sclerosis,strict definition

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Drugs most likely to be purchased after Systemic sclerosis,strict definition