Wet age-related macular degeneration

WET_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not WET_AMD_EARLY

356005

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Filter registries

Hospital Discharge: ICD-10 H35.31
Hospital discharge: ICD-9 3625B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 H35.31
Cause of death: ICD-9 3625B
Cause of death: ICD-8 $!$

4320

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Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE>=50
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4320

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Check minimum number of events None

4320

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Include endpoints None

4320

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WET_AMD

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Degeneratio maculae senilis exsudativa

Summary Statistics

Key figures

All Female Male
Number of individuals 4320 2191 2129
Unadjusted prevalence (%) 1.21 1.10 1.35
Mean age at first event (years) 75.52 75.65 75.39

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.80 [2.06, 3.81] 6.4e-11 837
15 years 0.01 1.30 [0.94, 1.79] 1.1e-1 378
5 years 0.00 2.46 [2.00, 3.03] 2.7e-17 337
1 year 0.00 3.24 [2.49, 4.23] 3.8e-18 93

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: WET_AMD – Wet age-related macular degeneration
GWS hits: 16

Survival analyses between endpoints

Plot

before Wet age-related macular degeneration
after Wet age-related macular degeneration

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Drugs most likely to be purchased after Wet age-related macular degeneration