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Alzheimer’s disease (Early onset)

DOID EFO MESH SNOMED PheWeb

AD_EO

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F00.0*, F00.00*, F00.00*G30.0, G30.0, G30.0+F00.00
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 F00.0*, F00.00*, F00.00*G30.0, G30.0, G30.0+F00.00
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

1113

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1113

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Check minimum number of events None

1113

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Include endpoints None

1113

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AD_EO

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1113 490 623
Unadjusted prevalence (%) 0.31 0.25 0.40
Mean age at first event (years) 75.16 73.75 76.27

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.24 15.67 [12.50, 19.64] <1e-100 687
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AD_EO – Alzheimer’s disease (Early onset)
GWS hits:

Survival analyses between endpoints

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Plot

before Alzheimer’s disease (Early onset)
after Alzheimer’s disease (Early onset)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Alzheimer’s disease (Early onset)

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